In individuals who are obese, which hormone is associated with increased fat storage?

The hormone associated with increased fat storage in individuals who are obese is lipoprotein lipase (LPL). LPL is an enzyme that plays a crucial role in lipid metabolism, particularly in the uptake of triglycerides from the bloodstream into adipose (fat) tissue and muscle cells. When LPL activity is increased, it promotes greater fat storage by facilitating the conversion of circulating triglycerides into fatty acids, which can then be taken up by fat cells for storage.

In the context of obesity, LPL activity is often elevated, leading to enhanced fat accumulation. This increase in fat storage can create a cycle that reinforces obesity, as higher levels of stored fat can contribute to further metabolic changes and challenges in energy balance.

Ghrelin, on the other hand, is primarily known as the hunger hormone that stimulates appetite. Insulin, while it does facilitate fat storage, primarily serves to regulate blood glucose levels and is influenced by carbohydrate intake. Leptin is another hormone involved in energy regulation but is more associated with signaling satiety and energy expenditure rather than directly driving fat storage. Thus, LPL is uniquely positioned as a significant factor in the mechanism of increased fat storage in those who are obese.