Leptin is produced primarily by what type of cells?

Leptin is a hormone that plays a crucial role in regulating energy balance and body weight. It is primarily produced by adipose (fat) cells. These specialized cells release leptin in proportion to the amount of body fat stored, providing signals to the hypothalamus in the brain about energy status. When fat stores increase, leptin levels rise, leading to a decrease in appetite and an increase in energy expenditure. Conversely, when fat stores decrease, leptin levels drop, which can stimulate hunger and reduce energy expenditure.

The production of leptin by adipose tissue is significant because it helps maintain homeostasis in body weight. This regulatory function is pivotal in preventing obesity and other metabolic diseases. In contrast, muscle cells, liver cells, and bone cells do not produce leptin to a significant extent, as their primary functions and roles in energy metabolism differ markedly from those of adipose tissue. Thus, understanding the primary source of leptin production is essential in the study of nutrition and metabolism.